Sarcomatoid Renal Cell Carcinoma

Renal cell carcinomas account for about 90 percent of all kidney cancers.

Sarcomatoid renal cell carcinoma.

Most trials report on a poor median overall survival of 5 to 12 months. Volume 15 pages 287 to91. Renal cell carcinoma occurs when cancer cells form in the tubules of the kidney. Current therapeutic approaches are largely ineffective.

Sarcomatoid renal cell carcinoma v arnoux and others prog urology 2013. It is characterized by a high propensity for primary metastasis and limited therapeutic options due to its relative resistance to established systemic targeted therapy. Recent studies looking into the genomic and molecular characterization of srccs have provided. Clear cell areas are golden in color due to cellular lipid accumulation while sarcomatoid foci are white.

Sarcomatoid renal cell carcinoma arising from a clear cell renal cell carcinoma lower left. Renal cell carcinoma rcc with sarcomatoid differentiation belongs to the most aggressive clinicopathologic phenotypes of rcc. Sarcomatoid transformation in renal cell carcinoma so called sacromatoid rcc srcc is associated with an aggressive behavior and a poor prognosis. The sarcomatoid variety while previously considered a distinct histologic subtype is now categorized as a form of dedifferentiated carcinoma.

To get more information on renal cell carcinoma visit the web site of the american cancer society. Sorafenib after combination therapy with gemcitabine plus doxorubicine in patients with sarcomatoid renal cell carcinoma. Renal cell carcinoma rcc is the most common malignancy of the kidney and consists of multiple subtypes. The biggest factor affecting the outlook for kidney cancer is the stage of the disease when it s diagnosed.

Renal cell carcinoma rcc also called renal cell cancer or renal cell adenocarcinoma is a common type of kidney cancer. Many studies have defined a tumor as srcc if even a. Definition of sarcomatoid renal cell carcinoma sarcomatoid renal cell carcinoma srcc is currently defined in the 2004 world health organization who classification of renal tumors as any histologic type of renal cell carcinoma rcc containing foci of high grade malignant spindle cells.