Parp Inhibitor Breast Cancer Side Effects

The side effects of parp inhibitors can usually be controlled or reduced and those described here will not affect everyone.

Parp inhibitor breast cancer side effects.

The most common side effects of parp inhibitors are. They are a treatment for some women with ovarian cancer. And low white blood cell counts. Side effects requiring immediate medical attention.

Introduction poly adp ribose polymerase parp inhibitors are a class of oral anticancer medications that have the most evidence for use in patients with inherited germline mutations. Common parp inhibitor side effects. Parp is a protein found in our cells it stands for poly adp ribose polymerase. In general parp inhibitors cause fewer and less serious side effects than some other cancer treatments.

All parp inhibitors are swallowed as a pill and the timing and dosage of the drug varies based on which type of parp inhibitor you re prescribed. Commonly reported side effects of olaparib include. Parp inhibitors for treating breast cancer lynparza and talzenna have received fda approval for treating metastatic breast cancer caused by a brca mutation. Lung and airway infection or inflammation.

We spoke to dr. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp. Like any drugs parp inhibitors can cause side effects and different ones will have varying effects. Upper respiratory tract infection anemia decreased hemoglobin increased mcv increased serum creatinine nasopharyngitis nausea pharyngitis vomiting cough and dyspnea.

Ursula matulonis chief of gynecologic oncology at the dana farber cancer institute to learn more about these potential side effects. It helps damaged cells to repair themselves. Everyone reacts differently to drugs and some people have more side effects than others. Parp inhibitors are a type of targeted cancer drug.

Based on clinical trial results the national comprehensive cancer network nccn added lynparza as a preferred treatment for people with advanced breast cancer and a brca mutation. Headache they can also cause low red blood cell counts called anemia which can lead to fatigue and other problems. They are also in trials as a treatment for other types of cancer. Here two oncology pharmacists discuss the side effects of parp inhibitor treatment and how to prevent and treat nausea and vomiting in this patient population.

Side effects of parp inhibitors.