Parp Inhibitor Adverse Effects

Lastly additional gi adverse effects that should be monitored with parp inhibitor use include constipation diarrhea abdominal pain dyspepsia dysgeusia and decreased appetite 2 5 conclusion.

Parp inhibitor adverse effects.

Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy radiotherapy or certain other medicines for their cancer have developed mds or aml. See below for a comprehensive list of adverse effects. These side effects may go away during treatment as your body adjusts to the medicine. While there are general side effects for a type of treatment they vary for each individual drug.

Side effects not requiring immediate medical attention. Regardless of which type all parp inhibitors share possible common side effects. Some side effects of niraparib may occur that usually do not need medical attention. Side effects requiring immediate medical attention.

Common side effects of parp inhibitors include. The common side effects for all parp inhibitors can include. The most common side effects associated with parp inhibitors are nausea vomiting and fatigue. Parp inhibitors can affect blood cells and the most common serious side effects of niraparib were lower than normal levels of red blood cells anemia platelets thrombocytopenia and white blood cells neutropenia.

Tell your doctor or nurse if you have any of these side effects. Common parp inhibitor side effects. All treatments can cause side effects. You might be able to have medicines to help control them.

They are developed for multiple indications including the treatment of heritable cancers. Also your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp. Generally speaking though most women can continue to go about their daily lives while taking these drugs.

Findings from the prima trial were published september 28 in the new england journal of medicine. Targeted therapies such as poly adp ribose polymerase parp inhibitors have emerged as one of the most exciting new treatments for ovarian cancer particularly in women with brca1 or brca2 mutations or those without a functional homologous recombination repair pathway. Providers should be aware of the potential risk for gi toxicity with parp inhibitors. The most common side effects associated with parp inhibitors are nausea vomiting and fatigue.

All parp inhibitors are swallowed as a pill and the timing and dosage of the drug varies based on which type of parp inhibitor you re prescribed. Bone marrow problems called myelodysplastic syndrome mds or acute myeloid leukemia aml. Lynparza may cause serious side effects including. Generally speaking though most women can continue to go about their daily lives while taking.

Upper respiratory tract infection anemia decreased hemoglobin increased mcv increased serum creatinine nasopharyngitis nausea pharyngitis vomiting cough and dyspnea.